The premier locality for Datolite, forming huge, well-shaped crystals is the Bor Pit, Dal'negorsk, Primorskiy Kray, Russia. Datolite lining vugs and geodes come from Tiso (Teis) in Italy, and are known locally as Teis Spheres. An unusual manganese-rich, pink variety of Datolite comes from the Kalahari Manganese Field of South Africa at the Wessels Mine in Hotazel and the N'Chwaning Mines in Kuruman. In Mexico, large, lustrous crystals associated with Danburite come from Charcas, San Luis Potosí, Mexico.
In the U.S., some of the best Datolite crystals come from the Roncari Quarry, East Granby, Hartford Co., Connecticut. Large crystals are well-known from the Lane Quarry, Westfield, Hampden Co., Massachusetts. The traprock quarries of Northern New Jersey have also produced excellent examples of Datolite, with some of the more prolific producers mentioned below: Large, well formed crystals have come both Prospect Park and Paterson, Passaic Co. Gemmy green Datolite crystal plates have from the Braens Quarry, Haledon, Passaic Co; and platy lustrous crystals from the Millington Quarry, Somerset Co. A classic locality is Bergen Hill, Hudson Co.; where Datolite occurred in diabase seams.
Porcelainous Datolite nodules that are often sliced and polished for collectors are unique to the Keweenaw Peninsula Copper Mining District in Michigan. These mineralogical oddities come in a range of colors and patterns, and are found in many of the Copper mines in the region. Some of the more notable mines in that area include the Centennial Mine, Hancock Mine, and Quincy Mine, in Houghton Co.; the Copper Falls Mine, Clark Mine, Delaware Mine, and Keweenaw Point in Keweenaw Co.; and the Caledonia Mine, Flintsteel Mine, and the Mass Mine, in Ontonagon Co.