Safflorite belongs to the Loellingite group, which is a group of chemically related isomorphous minerals that are all rare. Other members discussed in this guide are Loellingite and Rammelsbergite.
Safflorite oxidizes to form the pink cobalt mineral Erythrite. Safflorite may also form as a pseudomorph of Silver.
Safflorite is a rare mineral with few occurrences. It was found in Germany in Wittichen, Black Forest, Baden-Wurttemberg; and in Schlema-Hartenstein and Schneeberg, in the Erzgebirge, Saxony. It was also found in the Lill Mine, Pribram, Bohemia, Czech Republic;
Bou Azzer, Morocco; the Castle and O'Brien Mines, Cobalt, Timiskaming District, Ontario, Canada; and the Olafsen Iron Mine, Hereford Township, Berks Co., Pennsylvania.